Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

doi:10.1016/j.stemcr.2016.08.005

Article

Improved Human Erythropoiesis and Platelet Formation in Humanized NSGW41 Mice

12 Sept 2016

Abstract excerpt

Human erythro-megakaryopoiesis does not occur in humanized mouse models, preventing the in vivo analysis of human hematopoietic stem cell (HSC) differentiation into these lineages in a surrogate host. Here we show that stably engrafted KIT-deficient NOD/SCID Il2rg −/− Kit W41/W41 (NSGW41) mice support much improved human erythropoiesis and platelet formation compared with irradiated NSG recipients. Considerable...

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