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Article

Long-term engraftment of adult hematopoietic progenitors in a novel model of humanized mice

2023-10-03

Abstract excerpt

Pre-clinical use of humanized mice transplanted with CD34 + hematopoietic progenitor cells (HPCs) is limited by insufficient engraftment with adult HPCs. Here, we developed a novel immunodeficient mice based in NOD-SCID- Il2γc -/- (NSG) mice to support long-term engraftment with human adult HPCs and tissue colonization with human myeloid cells. As both Flt3L and IL-6 are critical for many aspects of hematopoiesi...

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Literature Corpus work
e5cded9c-bdd1-59e4-b72c-bb9dfd9d2f34
DOI
10.1101/2023.10.02.560534
Open publication

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Long-term engraftment of adult hematopoietic progenitors in a novel model of humanized miceDOI 10.1101/2023.10.02.560534
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