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Article

Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice.

Stem cell research & therapy - 21 Jun 2024

Ito Ryoji, Ohno Yusuke, Mu Yunmei, Ka Yuyo, Ito Shuko, Emi-Sugie Maiko, Mochizuki Misa, Kawai Kenji, Goto Motohito, Ogura Tomoyuki, Takahashi Riichi, Niwa Akira, Nakahata Tatsutoshi, Ito Mamoru

Abstract excerpt

Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human CD34+ HSCs and total-body irradiation for adequate engraftment. Recently, we generated a NOG mouse strain with a point mutation in the c-kit tyrosine kinase domain (W41 mutant;...

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Identifiers

PMID: 38902833
DOI: 10.1186/s13287-024-03799-w
PMCID: PMC11191313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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