Article
Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations.
Stem cell reports - 13 Sept 2016
Yurino Ayano, Takenaka Katsuto, Yamauchi Takuji, Nunomura Takuya, Uehara Yasufumi, Jinnouchi Fumiaki, Miyawaki Kohta, Kikushige Yoshikane, Kato Koji, Miyamoto Toshihiro, Iwasaki Hiromi, Kunisaki Yuya, Akashi Koichi
Abstract excerpt
In human-to-mouse xenograft models, reconstitution of human hematopoiesis is usually B-lymphoid dominant. Here we show that the introduction of homozygous Kit(Wv) mutations into C57BL/6.Rag2(null)Il2rg(null) mice with NOD-Sirpa (BRGS) strongly promoted human multi-lineage reconstitution. After xenotransplantation of human CD34(+)CD38(-) cord blood cells, these newly generated...
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