Article
Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.
Experimental hematology - 1 Apr 2017
Miller Paul H, Rabu Gabrielle, MacAldaz Margarita, Knapp David J H F, Cheung Alice M S, Dhillon Kiran, Nakamichi Naoto, Beer Philip A, Shultz Leonard D, Humphries R Keith, Eaves Connie J
Abstract excerpt
Xenograft models are transforming our understanding of the output capabilities of primitive human hematopoietic cells in vivo. However, many variables that affect posttransplantation reconstitution dynamics remain poorly understood. Here, we show that an equivalent level of human chimerism can be regenerated from human CD34+ cord blood cells transplanted intravenously either with or without additional...
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