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Multiomic single-cell analysis identifies von Willebrand factor and TIM3-expressing <i>BCR-ABL1</i> <sup>+</sup> CML stem cells

2023-09-17

Abstract excerpt

Tyrosine kinase inhibitors (TKI) only rarely eradicate leukemic stem cells (LSC) in chronic myeloid leukemia (CML) which commonly necessitates life-long therapy and monitoring of patients. Understanding details of leukemic hematopoiesis in CML may identify targetable pathways for sustained LSC elimination. This study utilized multiomic single-cell characterization of the CD14 - CD34 + hematopoietic stem and prog...

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Literature Corpus work: 17f79a07-43de-53f3-bf22-40f1a496e49c
DOI: 10.1101/2023.09.14.557507

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Multiomic single-cell analysis identifies von Willebrand factor and TIM3-expressing <i>BCR-ABL1</i> <sup>+</sup> CML stem cellsDOI 10.1101/2023.09.14.557507Read

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