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How to drug a leukemic stem cell: deciphering heterogeneity for better specificity

25 Jul 2025

Abstract excerpt

Blood cancers, such as acute myeloid leukemia (AML), are becoming increasingly common due to an aging population but remain challenging to treat. Relapse is the most important singular cause of treatment failure in AML, and up to half of patients relapse after chemotherapy or bone marrow transplantation. Relapse in AML is primarily due to a population of quiescent leukemic stem cells (LSCs) that shelter in the...

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PMID: 41424935
DOI: 10.1016/j.bneo.2025.100146

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