Article

Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4

2021-02-12

Abstract excerpt

<title>Abstract</title> <bold>Background:</bold> Apolipoprotein E4 (<italic>APOE4</italic>) is associated with a greater response to neuroinflammation and the risk of developing late-onset Alzheimer's disease (AD), but the mechanisms for this association are not clear. The activation of calcium-dependent cytosolic phospholipase A2 (cPLA2) is involved in inflammatory signaling and is elevated within the plaques...

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Literature Corpus work: 42a18ee5-da0c-5ccd-b172-27bbd8d382ff
DOI: 10.21203/rs.3.rs-68804/v3

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