Article

Eicosanoid Lipidome Activation in the APOE4 Brain with Dementia

2022-04-04

Abstract excerpt

<h4>Background: </h4> Chronic neuroinflammation is one of the hallmarks of late-onset Alzheimer’s disease (AD) dementia pathogenesis. Carrying the Apolipoprotein ε4 ( APOE4 ) allele has been associated with an accentuated response to brain inflammation and increases the risk of AD dementia progression. Among inflammation signaling pathways, aberrant eicosanoid activation plays a prominent role in neurodegeneration...

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Literature Corpus work: ff3731f7-6c03-5217-a7db-422cc8d4c746
DOI: 10.21203/rs.3.rs-1491984/v1

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