Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.

doi:10.1038/bjc.2017.133

Article

Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.

British journal of cancer - 27 Jun 2017

Nikkilä Jenni, Kumar Rahul, Campbell James, Brandsma Inger, Pemberton Helen N, Wallberg Fredrik, Nagy Kinga, Scheer Ildikó, Vertessy Beata G, Serebrenik Artur A, Monni Valentina, Harris Reuben S, Pettitt Stephen J, Ashworth Alan, Lord Christopher J

Abstract excerpt

BACKGROUND: Elevated APOBEC3B expression in tumours correlates with a kataegic pattern of localised hypermutation. We assessed the cellular phenotypes associated with high-level APOBEC3B expression and the influence of p53 status on these phenotypes using an isogenic system. METHODS: We used RNA interference of p53 in cells with inducible APOBEC3B and assessed DNA damage response (DDR) biomarkers. The mutational...

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Elevated APOBEC3B expression drives a kataegic-like mutation signature and replication stress-related therapeutic vulnerabilities in p53-defective cells.

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