Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia

Abstract excerpt

We previously found that T-cell acute lymphoblastic leukemia (T-ALL) requires support from tumor-associated myeloid cells, which activate IGF1R signaling in the leukemic blasts. However, IGF1 is not sufficient to sustain T-ALL survival in vitro, implicating additional myeloid-mediated signals in T-ALL progression. Here, we find that T-ALL cells require close contact with myeloid cells to survive. Transcriptional p...

Topics

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• Acute Myeloid Leukemia Research
• Cell Adhesion Molecules Research
• Chronic Lymphocytic Leukemia Research
• Gene Rearrangement
• Genetic Heterogeneity
• High-Throughput Nucleotide Sequencing
• Myeloid-Lymphoid Leukemia Protein
• Precursor Cell Lymphoblastic Leukemia-Lymphoma

Identifiers and source

Literature Corpus work

427e509f-d45f-5c11-a54d-a27c0b829b9b

DOI

10.1101/2022.01.05.475106