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TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia

2 Oct 2006

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is a clonal disease that evolves through the accrual of genetic rearrangements and/or mutations within the dominant clone. The TEL-AML1 (ETV6-RUNX1) fusion in precursor-B (pre-B) ALL is the most common genetic rearrangement in childhood cancer; however, the cellular origin and the molecular pathogenesis of TEL-AML1-induced leukemia have not been identified. To study the origin...

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PMID: 17015828
DOI: 10.1073/pnas.0603349103

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