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Cadherins, Selectins, and Integrins in CAM-DR in Leukemia

10 Dec 2020

Abstract excerpt

The interaction between leukemia cells and the bone microenvironment is known to provide drug resistance in leukemia cells. This phenomenon, called cell adhesion-mediated drug resistance (CAM-DR), has been demonstrated in many subsets of leukemia including B- and T-acute lymphoblastic leukemia (B- and T-ALL) and acute myeloid leukemia (AML). Cell adhesion molecules (CAMs) are surface molecules that allow...

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PMID: 33425742
DOI: 10.3389/fonc.2020.592733

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