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Article

Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia

27 Mar 2020

Abstract excerpt

Resistance to multimodal chemotherapy continues to limit the prognosis of acute lymphoblastic leukemia (ALL). This occurs in part through a process called adhesion-mediated drug resistance, which depends on ALL cell adhesion to the stroma through adhesion molecules, including integrins. Integrin α6 has been implicated in minimal residual disease in ALL and in the migration of ALL cells to the central nervous...

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PMID: 32219444
DOI: 10.1182/blood.2019001417

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