Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLL-AF9 leukemia stem cells: hardwired or taking cues from the microenvironment?

Cancer cell - 1 Jun 2008

Muntean Andrew G, Hess Jay L

Abstract excerpt

MLL rearrangements in humans lead to both acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL). While AML has been successfully produced in mice, modeling ALL has been more difficult. In this issue of Cancer Cell, Wei et al. (2008) describe generation of AML, ALL, and biphenotypic leukemia by manipulating the cytokine milieu of human progenitor cells expressing MLL-AF9. They demonstrate that both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Gene Expression Regulation, Leukemic
Share to Multipotent Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid-Lymphoid Leukemia Protein

Share to Neoplastic Stem Cells

Share to Oncogene Proteins, Fusion

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to rac GTP-Binding Proteins

Source

Identifiers

PMID: 18538728
DOI: 10.1016/j.ccr.2008.05.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLL-AF9 leukemia stem cells: hardwired or taking cues from the microenvironment?PMID 18538728Read ↗

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.Semantic proximity Read ↗

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitmentSemantic proximity Read ↗

MLL-AF9 Expression in Hematopoietic Stem Cells Drives a Highly Invasive AML Expressing EMT-Related Genes Linked to Poor OutcomeSemantic proximity Read ↗

MLL leukemia induction by genome editing of human CD34+ hematopoietic cellsSemantic proximity Read ↗

Identification of CD34+ and CD34− leukemia-initiating cells in MLL-rearranged human acute lymphoblastic leukemiaSemantic proximity Read ↗

Inducible MLL-AF9 expression drives an AML program during human pluripotent stem cell-derived hematopoietic differentiationSemantic proximity Read ↗

The AF4·MLL fusion protein is capable of inducing ALL in mice without requirement of MLL·AF4Semantic proximity Read ↗

Deciphering the Complexities of Acute Myeloid Leukemia: Emerging Roles of Epithelial to Mesenchymal Transition Transcription Factors (EMT-TFs) in Disease ProgressionSemantic proximity Read ↗

The ongoing conundrum of MLL-AF4 driven leukemogenesisSemantic proximity Read ↗

MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.Semantic proximity Read ↗

Evolutionarily conserved signaling pathways: acting in the shadows of acute myelogenous leukemia's genetic diversity.Semantic proximity Read ↗

Hematopoietic Stem Cells Are Intrinsically Protected against MLL-ENL-Mediated TransformationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.