Article

Protein Tyrosine Phosphatase 4A3 (PTP4A3) modulates Src signaling in T-cell Acute Lymphoblastic Leukemia to promote leukemia migration and progression

2019-06-24

Abstract excerpt

T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive blood cancer, and currently, there are no immunotherapies or molecularly targeted therapeutics available for treatment of this malignancy. The identification and characterization of genes and pathways that drive T-ALL progression is critical for development of new therapies for T-ALL. Here, we determined that Protein Tyrosine Phosphatase 4A3 (PTP4A3) pla...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4d31dc24-9bba-5fc1-9e2b-cf6b03e8828c
DOI: 10.1101/681791

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Protein Tyrosine Phosphatase 4A3 (PTP4A3) modulates Src signaling in T-cell Acute Lymphoblastic Leukemia to promote leukemia migration and progressionDOI 10.1101/681791Read

Pan-cancer analysis revealing that PTPN2 is a indicator of risk stratification for acute myeloid leukemia identification of high-risk patientsSemantic proximity Read

Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesisSemantic proximity Read

Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemiaSemantic proximity Read

The Key Roles of PTEN in T-Cell Acute Lymphoblastic Leukemia Development, Progression, and Therapeutic ResponseSemantic proximity Read

A comprehensive prognostic and immune analysis of LAPTM4B in pan-cancer and Philadelphia chromosome-positive acute lymphoblastic leukemiaSemantic proximity Read

Pre-T cell receptor signaling drives leukemogenesis and is a therapeutic target in T-cell acute lymphoblastic leukemiaSemantic proximity Read

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model.Semantic proximity Read

CCR9 overexpression promotes T-ALL progression by enhancing cholesterol biosynthesisSemantic proximity Read

MicroRNA expression and activity in T-cell acute lymphoblastic leukemiaSemantic proximity Read

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemiaSemantic proximity Read

Dysregulation of the inside-out signaling pathway in CNS-infiltrated pediatric T-cell acute lymphoblastic leukemiaSemantic proximity Read