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Article

The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia.

Haematologica - 1 Apr 2018

Marke René, van Leeuwen Frank N, Scheijen Blanca

Abstract excerpt

Transcription factor IKZF1 (IKAROS) acts as a critical regulator of lymphoid differentiation and is frequently deleted or mutated in B-cell precursor acute lymphoblastic leukemia. IKZF1 gene defects are associated with inferior treatment outcome in both childhood and adult B-cell precursor acute lymphoblastic leukemia and occur in more than 70% of BCR-ABL1-positive and BCR-ABL1-like cases of acute lymphoblastic...

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Source

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Identifiers

PMID: 29519871
DOI: 10.3324/haematol.2017.185603
PMCID: PMC5865415

Genes

IKZF1
ABL1
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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