Integrins regulate stemness in solid tumor: an emerging therapeutic target.

Abstract excerpt

Integrins are the adhesion molecules and transmembrane receptors that consist of α and β subunits. After binding to extracellular matrix components, integrins trigger intracellular signaling and regulate a wide spectrum of cellular functions, including cell survival, proliferation, differentiation and migration. Since the pattern of integrins expression is a key determinant of cell behavior in response to...

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• Cell Adhesion
• Cell Adhesion Molecules Research
• Integrins
• Mutation
• Neoplasms