Article

Deletion of endocannabinoid synthesizing enzyme DAGLα from cerebellar Purkinje cells decreases social preference and elevates anxiety

2024-08-08

Abstract excerpt

<h4>ABSTRACT</h4> The endocannabinoid (eCB) signaling system is robustly expressed in the cerebellum starting from the embryonic developmental stages to adulthood. There it plays a key role in regulating cerebellar synaptic plasticity and excitability, suggesting that impaired eCB signaling will lead to deficits in cerebellar adjustments of ongoing behaviors and cerebellar learning. Indeed, human mutations in DA...

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Literature Corpus work: 42624dd2-edb3-5f72-85e0-44d097315aab
DOI: 10.1101/2024.08.08.607068

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