Lack of kinase‐independent activity of PI3Kγ in locus coeruleus induces ADHD symptoms through increased CREB signaling

Abstract excerpt

Although PI3Kγ has been extensively investigated in inflammatory and cardiovascular diseases, the exploration of its functions in the brain is just at dawning. It is known that PI3Kγ is present in neurons and that the lack of PI3Kγ in mice leads to impaired synaptic plasticity, suggestive of a role in behavioral flexibility. Several neuropsychiatric disorders, such as attention-deficit/hyperactivity disorder...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Attention Deficit Hyperactivity Disorder
• Share to Phosphodiesterase function and regulation
• Share to Receptor Mechanisms and Signaling