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Article

Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice.

The European journal of neuroscience - 1 May 2001

Miyata M, Kim H T, Hashimoto K, Lee T K, Cho S Y, Jiang H, Wu Y, Jun K, Wu D, Kano M, Shin H S

Abstract excerpt

Long-term depression (LTD) at parallel fibre-Purkinje cell synapse of the cerebellum is thought to be a cellular substrate for motor learning. LTD requires activation of metabotropic glutamate receptor subtype 1 (mGluR1) and its downstream signalling pathways, which invariably involves phospholipase Cbetas (PLCbetas). PLCbetas consist of four isoforms (PLCbeta1-4) among which PLCbeta4 is the major isoform in most...

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Source

Identifiers

PMID: 11403688
DOI: 10.1046/j.0953-816x.2001.01570.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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