Article
Cerebellar Purkinje cell p75 neurotrophin receptor and autistic behavior.
Translational psychiatry - 29 Jul 2014
Lotta L T, Conrad K, Cory-Slechta D, Schor N F
Abstract excerpt
The p75 neurotrophin receptor (p75NTR) is normally expressed in cerebellar Purkinje cells throughout the lifespan. Children with autism spectrum behavior exhibit apparent cerebellar Purkinje cell loss. Cerebellar transcriptome changes seen in the murine prenatal valproate exposure model of autism include all of the proteins known to constitute the p75NTR interactome. p75NTR is a modulator of cytoplasmic and...
Topics
- Agonistic Behavior
- Animals
- Autistic Disorder
- Disease Models, Animal
- Gene Expression
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Phenotype
- Purkinje Cells
- Receptors, Nerve Growth Factor
- Socialization
- Stereotyped Behavior
- Transcriptome