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Article

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

25 Sept 2012

Abstract excerpt

Fragile X syndrome, the most commonly known genetic cause of autism, is due to loss of the fragile X mental retardation protein, which regulates signal transduction at metabotropic glutamate receptor-5 in the brain. Fragile X mental retardation protein deletion in mice enhances metabotropic glutamate receptor-5-dependent long-term depression in the hippocampus and cerebellum. Here we show that a distinct type of...

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PMID: 23011134
DOI: 10.1038/ncomms2045

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