Article

A novel mouse model for developmental and epileptic encephalopathy by Purkinje cell-specific deletion of <i>Scn1b</i>

2024-11-19

Abstract excerpt

Loss of function variants of SCN1B are associated with a range of developmental and epileptic encephalopathies (DEEs), including Dravet syndrome. These DEEs feature a wide range of severe neurological disabilities, including changes to social, motor, mood, sleep, and cognitive function which are notoriously difficult to treat, and high rates of early mortality. While the symptomology of SCN1B -associated DEEs in...

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Literature Corpus work: 960dea30-191d-5666-8c68-9aaf056b496d
DOI: 10.1101/2024.11.19.624370

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