Back to search

Article

The LARP1 RRM functions as a ribosome responsive regulator of TOP mRNAs

2026-04-19

Abstract excerpt

The synthesis of ribosomes in metazoans is an essential process that is dysregulated in disease. Previous studies implicate La-related protein 1 (LARP1) in binding inactive ribosomes and in repressing Terminal OligoPyrimidine motif mRNAs (TOPs), which encode ribosomal proteins. While the molecular details of LARP1 binding to the ribosome and to TOP mRNAs are deciphered, the mechanistic link between these two activ...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
42621b8d-3074-56a0-b030-54ac822b7ac2
DOI
10.64898/2026.04.18.719249
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The LARP1 RRM functions as a ribosome responsive regulator of TOP mRNAsDOI 10.64898/2026.04.18.719249
Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity
Distinct roles of LARP1 and 4EBP1/2 in regulating translation and stability of 5′TOP mRNAsSemantic proximity
Control of ribosomal protein synthesis by Microprocessor complexSemantic proximity
La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast.Semantic proximity
Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translationSemantic proximity
LARP4 Is an RNA-Binding Protein That Binds Nuclear-Encoded Mitochondrial mRNAs To Promote Mitochondrial FunctionSemantic proximity
<i>In vivo</i> single-cell CRISPR screening for microproteins identifies a critical ribosomal componentSemantic proximity
The short conserved region-2 of LARP4 interacts with ribosome-associated RACK1 and promotes translation.Semantic proximity
Decoding regulatory specificity of human ribosomal proteinsSemantic proximity
Multi-omics analysis reveals CMTR1 upregulation in cancer and roles in ribosomal protein gene expression and tumor growthSemantic proximity
La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.Semantic proximity
Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiationSemantic proximity
Select a neighboring publication to make it the new centre.