Article

Control of ribosomal protein synthesis by Microprocessor complex

2020-04-25

Abstract excerpt

Ribosome biogenesis in eukaryotes requires stoichiometric production and assembly of 80 ribosomal proteins (RPs) and 4 ribosomal RNAs, and its rate must be coordinated with cellular growth. The indispensable regulator of RP biosynthesis is the 5’-terminal oligopyrimidine (TOP) motif, spanning the transcription start site of all RP genes. Here we show that the Microprocessor complex, previously linked to the first...

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Literature Corpus work: 1297f46e-33a6-54e7-a8db-de57d09a5df3
DOI: 10.1101/2020.04.24.060236

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