Article
La-motif-dependent mRNA association with Slf1 promotes copper detoxification in yeast.
RNA (New York, N.Y.) - 1 Mar 2012
Schenk Luca, Meinel Dominik M, Strässer Katja, Gerber André P
Abstract excerpt
The La-motif (LAM) is an ancient and ubiquitous RNA-binding domain defining a superfamily of proteins, which comprises the genuine La proteins and La-related proteins (LARPs). In contrast to La, which binds and stabilizes pre-tRNAs and other RNA polymerase III transcripts, data on function and RNA targets of the LARPs have remained scarce. We have undertaken a global approach to elucidate the previously suggested...
Topics
- Amino Acid Motifs
- Amino Acid Sequence
- Biotransformation
- Cluster Analysis
- Copper
- Cytoplasm
- Fungal Proteins
- Gene Expression
- Gene Expression Regulation, Fungal
- Molecular Sequence Data
- Mutation