Article
La-related protein 4 binds poly(A), interacts with the poly(A)-binding protein MLLE domain via a variant PAM2w motif, and can promote mRNA stability.
Molecular and cellular biology - 1 Feb 2011
Yang Ruiqing, Gaidamakov Sergei A, Xie Jingwei, Lee Joowon, Martino Luigi, Kozlov Guennadi, Crawford Amanda K, Russo Amy N, Conte Maria R, Gehring Kalle, Maraia Richard J
Abstract excerpt
The conserved RNA binding protein La recognizes UUU-3'OH on its small nuclear RNA ligands and stabilizes them against 3'-end-mediated decay. We report that newly described La-related protein 4 (LARP4) is a factor that can bind poly(A) RNA and interact with poly(A) binding protein (PABP). Yeast two-hybrid analysis and reciprocal immunoprecipitations (IPs) from HeLa cells revealed that LARP4 interacts with RACK1, a...
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