Article

The assembly of cancer-specific ribosomes by the lncRNA <i>LISRR</i> suppresses melanoma anti-tumour immunity

2023-01-08

Abstract excerpt

Although immune checkpoint blockade (ICB) has revolutionized cancer treatment, resistance mechanisms limit its clinical benefit. Here we characterise LISRR , a cancer-specific lncRNA highly expressed in melanoma patients refractory to ICB. In cells undergoing (therapeutic) stress, LISRR recruits DAZAP1 (Deleted in AZoospermia Associated Protein 1) to polysomes and drives the assembly of a subset of ribosomes at...

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Literature Corpus work: 424c149b-88b1-5ad4-86ff-1928772260c9
DOI: 10.1101/2023.01.06.523012

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