Article

Induction of an alternative 5’ leader enhances translation of <i>Inpp5e</i> and resistance to oncolytic virus infection

2019-01-17

Abstract excerpt

<h4>ABSTRACT</h4> Residual cell-intrinsic innate immunity in cancer cells hampers infection with oncolytic viruses. mRNA translation is an important component of innate immunity, yet the targeted cellular mRNAs remain ill-defined. We characterized the translatome of resistant murine “4T1” breast cancer cells infected with three of the most clinically advanced oncolytic viruses: Herpes Simplex virus 1, Reovirus an...

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Literature Corpus work: 8c1ce132-dda7-53cd-ad21-dd8b04cec08d
DOI: 10.1101/522607

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