Article

Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancer

2025-02-27

Abstract excerpt

Triple-negative breast cancer (TNBC) remains one of the most challenging breast cancer subtypes to treat due to the lack of effective therapeutic options. Ribosome biogenesis has recently emerged as a promising therapeutic target across various cancers. Despite the current targeting of ribosome biogenesis through RNA polymerase I (RNA Pol I) inhibition, we speculated that other factors essential for ribosome assem...

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Literature Corpus work: e58249ec-1b32-5ca7-94fc-a7481147e3c7
DOI: 10.1101/2025.02.23.639238

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Fibrillarin-mediated ribosomal RNA maturation is a novel therapeutic vulnerability in triple-negative breast cancerDOI 10.1101/2025.02.23.639238Read

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