Hyperacute Response Proteins (HARPs) synthesized on γ-tubulin-FTO-MARK4 translation microdomains upon exposure to stress, regulate stress response in cancer

Abstract excerpt

<h4>Summary</h4> Compared to normal, cancer cells are particularly resistant to stress, and their immediate response to stress is critical for their subsequent multilayered adaptation programs which pose a major clinical challenge. With unbiased proteomics and transcriptomics analysis, we identified a list of HARPs synthesized from pre-existing mRNAs within 20 min of diverse stresses in A549 cancer cells, despite...

Topics

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• Cytoplasmic Granules
• Neoplasm Metastasis
• Protein Biosynthesis
• RNA, Neoplasm
• RNA Processing, Post-Transcriptional
• RNA Stability
• Tumor Microenvironment
• Y-Box-Binding Protein 1

Identifiers and source

Literature Corpus work

41e3dc69-9ecd-590c-8169-981b8c6ae485

DOI

10.1101/2025.01.20.633998