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Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy

11 Jul 2025

Abstract excerpt

BACKGROUND: Hyperactive ribosome biogenesis is a hallmark of tumours. Current ribosome-related studies are concentrated on cancer cells. Ribosomes can regulate both tumour and non-cancer cells within the tumour microenvironment, yet the immunomodulatory effects of cellular ribosome biogenesis blockade remain inadequately understood. METHODS: We performed ribosome-targeting therapy utilizing CX-5461, an effective...

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PMID: 40646287
DOI: 10.1038/s41416-025-03109-y

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