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Article

tRNA modifications are required for stress granule formation and melanoma metastasis

2025-08-25

Abstract excerpt

Metastasis is the leading cause of cancer related deaths, however therapies specifically targeting metastasis are lacking and remain a dire therapeutic need in the clinic. Metastasis is a highly inefficient process that is inhibited by extracellular stress. Therefore, metastasizing cells that ultimately survive and successfully colonize distant organs must undergo molecular rewiring to mitigate stress. Wobble urid...

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Identifiers and source

Literature Corpus work
a3e0db03-f6d2-5b75-acb3-7710418692dd
DOI
10.1101/2025.08.20.671337
Open publication

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tRNA modifications are required for stress granule formation and melanoma metastasisDOI 10.1101/2025.08.20.671337
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