Nanopore-based sequence deconvolution of diverse glycosaminoglycans

Abstract excerpt

Glycosaminoglycan (GAG) polysaccharides play vital roles in animal physiology and disease 1 . Their diverse and intricate patterns of sulfation and epimerization endow them with an extensive potential to encode functional information 2,3 . GAG characterization, however, remains a formidable challenge for state-of-the-art ensemble-based techniques 4,5 . Single-molecule techniques are uniquely suited for analysin...

Topics

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• Bacterial Toxins
• Cryoelectron Microscopy
• Glycosylation and Glycoproteins Research
• Molecular Docking Simulation
• Mutation
• Nanopores
• Polysaccharides
• Pore Forming Cytotoxic Proteins

Identifiers and source

Literature Corpus work

424ac3f2-b6a3-5a82-a8d9-010f0c562e1e

DOI

10.64898/2026.08.08.743666