Pathogen-sugar interactions revealed by universal saturation transfer analysis.

doi:10.1126/science.abm3125

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Article

Pathogen-sugar interactions revealed by universal saturation transfer analysis.

Science (New York, N.Y.) - 22 Jul 2022

Buchanan Charles J, Gaunt Ben, Harrison Peter J, Yang Yun, Liu Jiwei, Khan Aziz, Giltrap Andrew M, Le Bas Audrey, Ward Philip N, Gupta Kapil, Dumoux Maud, Tan Tiong Kit, Schimaski Lisa, Daga Sergio, Picchiotti Nicola, Baldassarri Margherita, Benetti Elisa, Fallerini Chiara, Fava Francesca, Giliberti Annarita, Koukos Panagiotis I, Davy Matthew J, Lakshminarayanan Abirami, Xue Xiaochao, Papadakis Georgios, Deimel Lachlan P, Casablancas-Antràs Virgínia, Claridge Timothy D W, Bonvin Alexandre M J J, Sattentau Quentin J, Furini Simone, Gori Marco, Huo Jiandong, Owens Raymond J, Schaffitzel Christiane, Berger Imre, Renieri Alessandra, Naismith James H, Baldwin Andrew J, Davis Benjamin G

Abstract excerpt

Many pathogens exploit host cell-surface glycans. However, precise analyses of glycan ligands binding with heavily modified pathogen proteins can be confounded by overlapping sugar signals and/or compounded with known experimental constraints. Universal saturation transfer analysis (uSTA) builds on existing nuclear magnetic resonance spectroscopy to provide an automated workflow for quantitating protein-ligand...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 35737812
DOI: 10.1126/science.abm3125

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