Quantitative Super-Resolution Microscopy of the Mammalian Glycocalyx

Abstract excerpt

The mammalian glycocalyx is a heavily glycosylated extramembrane compartment found on nearly every cell. Despite its relevance in both health and disease, studies of the glycocalyx remain hampered by a paucity of methods to spatially classify its components. We combine metabolic labeling, bioorthogonal chemistry, and super-resolution localization microscopy to image two constituents of cell-surface glycans, N-...

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• Click Chemistry and Applications
• Glycosylation and Glycoproteins Research
• Lung Neoplasms
• Monoclonal and Polyclonal Antibodies Research
• Mutation
• Pancreatic function and diabetes
• Polysaccharides
• Viral Infectious Diseases and Gene Expression in Insects

Identifiers and source

Literature Corpus work

289e9c8d-8ad1-5049-b98e-c0d91c359bd6

DOI

10.26434/chemrxiv.7381724.v1