Article

Effects of Neighboring Phosphorylation Events on the Affinities of pT181-Tau Antibodies

2023-09-13

Abstract excerpt

<h4>ABSTRACT</h4> A tau variant phosphorylated on threonine 181 (pT181-tau) has been widely investigated as a potential Alzheimer’s disease (AD) biomarker in cerebrospinal fluid (CSF) and blood. pT181-tau is present in neurofibrillary tangles (NFTs) of AD brains, and CSF levels of pT181-tau correlate with overall NFT burden. Various immuno-based analytical methods, including Western blotting and ELISA, have been...

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Literature Corpus work: 422405d3-c8ca-56ba-a491-b3a7c4ad1506
DOI: 10.1101/2023.09.10.557075

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