Article

Large-scale single-molecule analysis of tau proteoforms

2025-06-27

Abstract excerpt

<h4>ABSTRACT</h4> Proteins exist as diverse proteoforms resulting from a combination of genetic variation, alternative splicing, and post-translational modifications. Current methods struggle to capture this complexity at the single-molecule level. Here we introduce Iterative Ma pping of P roteoforms (IMaP), a method that enables the massively-parallel interrogation of millions to billions of single-protein mol...

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Literature Corpus work: 4e59540f-a613-5c15-9c5c-7e6cc26285b9
DOI: 10.1101/2025.06.26.660445

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