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Article

Deficiency of interferon-gamma or its receptor promotes colorectal cancer development.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Apr 2015

Wang Lu, Wang Yan, Song Zhiyu, Chu Jiahui, Qu Xianjun

Abstract excerpt

Genetic variations in interferon-gamma (IFN-γ) and its receptor (IFNγR) subunits are closely associated with the risk of colorectal cancer (CRC) and survival after diagnosis. However, the role of loss of IFN-γ or IFNγR function in the pathogenesis of CRC remains unclear. Here, we investigated the role of endogenous IFN-γ deficiency in adenomatous polyposis coli (Apc)-mediated intestinal tumor by developing a...

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Source

Identifiers

PMID: 25383957
DOI: 10.1089/jir.2014.0132

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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