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Article

Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activation.

The American journal of pathology - 1 May 2010

Newton Victoria A, Ramocki Nicole M, Scull Brooks P, Simmons James G, McNaughton Kirk, Lund P Kay

Abstract excerpt

Epigenetic in vitro and in vivo studies suggest that suppressor of cytokine signaling-2 (SOCS2) may normally limit tumorigenesis in the intestine; however, this theory has not been directly tested. We hypothesized that SOCS2 deficiency promotes spontaneous intestinal tumorigenesis in Apc(Min/+) mice. Therefore, we quantified tumor number, size, and load in the small intestine and colon using...

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Share to Epigenesis, Genetic
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Gene Silencing

Share to Genes, APC

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Share to Suppressor of Cytokine Signaling Proteins

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Source

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Identifiers

PMID: 20348236
DOI: 10.2353/ajpath.2010.090684
PMCID: PMC2861097

Genes

SOCS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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