Article
Winnie-APCMin/+ Mice: A Spontaneous Model of Colitis-Associated Colorectal Cancer Combining Genetics and Inflammation.
International journal of molecular sciences - 23 Apr 2020
De Santis Stefania, Verna Giulio, Serino Grazia, Armentano Raffaele, Cavalcanti Elisabetta, Liso Marina, Dicarlo Manuela, Coletta Sergio, Mastronardi Mauro, Lippolis Antonio, Tafaro Angela, Santino Angelo, Pinto Aldo, Campiglia Pietro, Huang Alex Y, Cominelli Fabio, Pizarro Theresa T, Chieppa Marcello
Abstract excerpt
(1) Background: Colorectal cancer (CRC) is among the best examples of the relationship between inflammation and increased cancer risk. (2) Methods: To examine the effects of spontaneous low-grade chronic inflammation on the pathogenesis of CRC, we developed a new murine model of colitis-associated cancer (CAC) by crossing Mucin 2 mutated mice (Winnie) with ApcMin/+ mice. (3) Results: The resulting Winnie-ApcMin/+...
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