Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A20 Restricts Wnt Signaling in Intestinal Epithelial Cells and Suppresses Colon Carcinogenesis

6 May 2013

Abstract excerpt

Colon carcinogenesis consists of a multistep process during which a series of genetic and epigenetic adaptations occur that lead to malignant transformation. Here, we have studied the role of A20 (also known as TNFAIP3), a ubiquitin-editing enzyme that restricts NFκB and cell death signaling, in intestinal homeostasis and tumorigenesis. We have found that A20 expression is consistently reduced in human colonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helicobacter pylori-related gastroenterology studies
Share to NF-κB Signaling Pathways
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23671587
DOI: 10.1371/journal.pone.0062223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A20 Restricts Wnt Signaling in Intestinal Epithelial Cells and Suppresses Colon CarcinogenesisPMID 23671587Read ↗

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis.Semantic proximity Read ↗

Lamin A/C regulates the compartment-specific contributions of immune and stromal cells to intestinal inflammation and colitis-associated colon cancerSemantic proximity Read ↗

Loss of E3 ligase Ube4A Disrupts Colon Homeostasis and Accelerates Experimental Colitis via Altered Lipid HandlingSemantic proximity Read ↗

Nuclear adenomatous polyposis coli suppresses colitis-associated tumorigenesis in mice.Semantic proximity Read ↗

Adenomatous polyposis coli in cancer and therapeutic implicationsSemantic proximity Read ↗

A20 prevents chronic liver inflammation and cancer by protecting hepatocytes from death.Semantic proximity Read ↗

Intestinal epithelial Axin1 deficiency protects against colitis via altered gut microbiotaSemantic proximity Read ↗

A20’s Linear Ubiquitin Binding Motif Restrains Pathogenic Activation of TH17/22 cells and IL-22 Driven EnteritisSemantic proximity Read ↗

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.Semantic proximity Read ↗

Loss of Adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22Semantic proximity Read ↗

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease.Semantic proximity Read ↗

Olfactomedin 4 deletion induces colon adenocarcinoma in ApcMin/+ mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.