Article

<i>KRAS</i> signalling in malignant pleural mesothelioma

2020-10-23

Abstract excerpt

Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural cavity of asbestos-exposed individuals and rapidly leads to the development of pleural effusion and death. MPM harbours loss-of-function mutations in genes like BAP1, NF2, CDKN2A , and TP53 , but isolated deletion of these genes alone in mice does not cause MPM and mouse models of the disease are sparse. Here we show that a sig...

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Literature Corpus work: 41fb8cd9-1f0a-59ff-9ce7-f3c4a33e2010
DOI: 10.1101/2020.10.22.350850

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