Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

doi:10.1002/jcp.26830

Article

Inactivation of Tp53 and Pten drives rapid development of pleural and peritoneal malignant mesotheliomas

15 Jun 2018

Abstract excerpt

Malignant mesothelioma (MM) is a therapy‐resistant cancer arising primarily from the lining of the pleural and peritoneal cavities. The most frequently altered genes in human MM are cyclin‐dependent kinase inhibitor 2A ( CDKN2A ), which encodes components of the p53 (p14ARF) and RB (p16INK4A) pathways, BRCA1‐associated protein 1 ( BAP1 ), and neurofibromatosis 2 ( NF2 ). Furthermore, the p53 gene ( TP53 ) itself...

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Inactivation of <i>Tp53</i> and <i>Pten</i> drives rapid development of pleural and peritoneal malignant mesotheliomas

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