Article

Isolated <i>BAP1</i> loss in malignant pleural mesothelioma predicts immunogenicity with implications for immunotherapeutic response

2022-05-10

Abstract excerpt

Malignant pleural mesothelioma (MPM), an aggressive cancer of the mesothelial cells lining the pleural cavity, lacks effective treatments. Multiple somatic mutations and copy number losses in tumor suppressor genes (TSGs) BAP1, CDKN2A/B , and NF2 are associated with MPM. The impact of single versus multiple losses of TSG on MPM biology, the immune tumor microenvironment, clinical outcomes, and treatment response...

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Literature Corpus work: 2bb990cc-cbd3-50f7-a8ec-5ed1dfde16bb
DOI: 10.1101/2022.05.06.490947

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