Article

Developmental and genetic regulation of the human cortex transcriptome in schizophrenia

2017-04-05

Abstract excerpt

<h4>Summary</h4> GWAS have identified 108 loci that confer risk for schizophrenia, but risk mechanisms for individual loci are largely unknown. Using developmental, genetic, and illness-based RNA sequencing expression analysis, we characterized the human brain transcriptome around these loci and found enrichment for developmentally regulated genes with novel examples of shifting isoform usage across pre- and post...

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Literature Corpus work: 64e40827-45e3-5963-bf6d-1c1b25d9d152
DOI: 10.1101/124321

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