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Article

Genome-wide identification of splicing QTLs in the human brain and their enrichment among schizophrenia-associated loci.

Nature communications - 27 Feb 2017

Takata Atsushi, Matsumoto Naomichi, Kato Tadafumi

Abstract excerpt

Detailed analyses of transcriptome have revealed complexity in regulation of alternative splicing (AS). These AS events often undergo modulation by genetic variants. Here we analyse RNA-sequencing data of prefrontal cortex from 206 individuals in combination with their genotypes and identify cis-acting splicing quantitative trait loci (sQTLs) throughout the genome. These sQTLs are enriched among exonic and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28240266
DOI: 10.1038/ncomms14519
PMCID: PMC5333373

Genes

FXR1
NEK4
SNAP91

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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