Article
Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights.
Nature genetics - 1 Apr 2018
Gusev Alexander, Mancuso Nicholas, Won Hyejung, Kousi Maria, Finucane Hilary K, Reshef Yakir, Song Lingyun, Safi Alexias, McCarroll Steven, Neale Benjamin M, Ophoff Roel A, O'Donovan Michael C, Crawford Gregory E, Geschwind Daniel H, Katsanis Nicholas, Sullivan Patrick F, Pasaniuc Bogdan, Price Alkes L
Abstract excerpt
Genome-wide association studies (GWAS) have identified over 100 risk loci for schizophrenia, but the causal mechanisms remain largely unknown. We performed a transcriptome-wide association study (TWAS) integrating a schizophrenia GWAS of 79,845 individuals from the Psychiatric Genomics Consortium with expression data from brain, blood, and adipose tissues across 3,693 primarily control individuals. We identified...
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