Article

Pyruvate Kinase M Links Glucose Availability to Protein Synthesis

2019-07-25

Abstract excerpt

How human cells coordinate various metabolic processes, such as glycolysis and protein translation, remains unclear. One key insight is that various metabolic enzymes have been found to associate with mRNAs, however whether these enzymes regulate mRNA biology in response to changes in cellular metabolic state remains unknown. Here we report that the glycolytic enzyme, pyruvate kinase M (PKM), inhibits the translat...

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Identifiers and source

Literature Corpus work: 41f12bc6-0a0f-5dc4-bf05-22b87b489557
DOI: 10.1101/715086

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